Korea Institute of Radiological & Medical Sciences

2020
- Publication of the book ⌜Radioimmunotherapy in KIRAMS⌟
- Holding a launching ceremony of KIRAMS Development Meeting
- Implementation of ‘research project about creating the radiation technology convergence cluster in capital area’
- Implementation E-learning on Radiation Medicine including Radiation Therapy
- Adoption of KIRAMS's international collaboration project as one of cooperation activities between Korea and IAEA
- 2 technology transfer
  - Technology Transfer Agreement Signed for the MASTL Inhibitor Portfolio(DLpharma)
  - Technology Transfer Agreement Signed for TED inhibitors(Boryung Pharmaceutical)
- KFDA apporoval for [64Cu]DOTA-rituximab microdosing clinical trial
- KFDA apporoval for phase 3 study of [18F]Florastamin PET in prostate cancer
2019
- Foundation for clinical research by researchers for diagnosis of brain diseases
- 6 technology transfers, 1 new drug venture start-up
  - Radiosensitizer containing Aripiprazole as an effective ingredient (VSPharmTech) : Patent and Trademark Office Award on Korea Invention Patent Exhibition 2019
  - SHVEA protein that increases the effectiveness of Huffis virus cell infection (Wellmarker Bio)
  - Cell therapy techniques for treating wounds (biosolutions.co)
  - Biomarker AROS Protein and Rictor (Gencellmed)
  - Anti-cancer drug & Radiosensitizer Include beta-apophycroopyline (J&C Sciences)
  - Development of MASTL - Based Tritic Breast Cancer Treatment Technologies (Dipharma)
- Selection of the first family business in 2019
2018
- Development of PET Radiopharmaceuticals for cervical cancer
- MicroRNA miR-4779 suppresses tumor growth by inducing apoptosis and cell cycle arrest through direct targeting of PAK2 and CCND3
- miR-550a-3-5p acts as a tumor suppressor and reverses BRAF inhibitor resistance through the direct targeting of YAP
- Study for Alzheimer Dementia using Diagnostic Radiopharmaceutical
- Evaluation index for Alzheimer Dementia using Diagnostic Radiopharmaceutical
- Tumour-vasculature development via endothelial-to-mesenchymal transition after radiotherapy controls CD44v6+ cancer cell and macrophage polarization
2017
- Clinical Trial Study for Alzheimer Dementia using Diagnostic Radiopharmaceutical
- Role of the p53/p21 complex, Bcl-2 family proteins, and respiratory complex I in the metastasis and recurrence of cancer cells
- Real-time monitoring of cellular proliferation in cancer using 19F MRI/MRS
- Radioimmunotherapy Overcomes Immunotherapy Resistant Head and Neck Squampus Cell Carcinoma
- Development and Clinical Trials of PET Radiopharmaceuticals for HER2 Positive Breast Cancer

2015
- Longitudinal monitoring adipose-derived stem cell survival by PET imaging using hexadecyl-4-124I-iodobenzoate in rat myocardial infarction model
- ERp57 modulates STAT3 activity in radioresistant laryngeal cancer cells and serves as a prognostic marker for laryngeal cancer
- Selective inhibition of histone deacetylase 2 induces p53- dependent survivin downregulation through MDM2 proteasomal degradation
- Aspirin Targets SIRT1 and AMPK to Induce Senescence of Colorectal Carcinoma Cells
- Ilhan Lim, Sang Moo Lim et al. Long-term outcomes of differentiated thyroid cancer with bone metastasis and the prognostic factors
- Stereotactic Body Radiotherapy for Oligometastases Confined to the Para-aortic Region-Clinical Outcomes and the Significance of Radiotherapy Field and Dose
2014
- Radioimmunotherapy with 131 I-rituximab for patients with B-cell non-Hodgkin's lymphoma
- Development of radiotherapy enhancement biomaterial based on individual gene of lung cancer patient
- Cetuximab inhibits cisplatin-induced activation of EGFR signaling in esophageal squamous cell carcinoma
- Development of convergence technology for diagnositc imaging and treatment of cancer using copper transporter gene expression
- Identification of the regulatory network of tumor metastasis
- defininig the role of vitamin D in the pathogenesis of mutated lung cancer
- Usefulness of Combined therapy with 131 I and Lithium in patients with metastatic radioiodine-refractory thyroid cancer
- KIRAMS achieves ISO 15189:2013 certificate from KOLAS on Biological Dosimetry for Radiation Emergency Preparedness
2013
- Implementation of radioactive isotope utilizing new treatment research and development of platform establishment program
- Identified new carcinogenic factor CIP2A cell division and PLK1 control function during tumorigenesis
2012
- Construction of experiment animal research hall
- Implementation of the first radiation promotion plan
- Establishment of radiology policy development center and focused training research center
- Development of radiation cancer treatment vitalization material through cancer cell aging control
2011
- Composition of functional interaction top of low-oxygen expression, radiation-resistant factors
- Development of disease-specific radio-virotherapy treatment efficiency improvement technology
- Development of motion tracking collimator treatment device and radiation treatment system
- Improved lymphoma patient survival rate through repeated radiation immunization treatment technology
- Radiation damage protection effect of HSP27
- Establishment of researcher-built company, Health Biomed

2010
- Development of liver cancer targeting bioluminescence imagery from liver cancer-inducing model
- Development of next-generation multipurpose/multi-function SPECT/MR dual contrast medium
- Development of biological reaction control function against radiation
- Production technology of hyaluronic acid deacetylated hydrolase, deacetylated hyaluronic acid and derivatives
- Development of core superconductivity cyclotron technology of K1720 for carbon beam treatment
- Development of new target utilizing radiation damage control agent
- Discovery of radiation reacting protein, Sialyltransferase (ST6Gal I), and identification of cancer metastasis control function
2009
- Discovering cancer cell aging discrimination substance (cathepsin D, eEF1)
- Development of diagnostic radioactive medicine and medical supplies (C-11 acetate) automation system
- Development of medical radioactive isotope I-124, Cu-64 production technology
- Development of radiation treatment transcription factor group (miRNA)
- Collaborated on research for liver cancer diagnostic candidate substance commercialization (Pfizer)
- Development of TGF-B activity inhibition composite including Imidazopyridine derivatives
- Building the first PET/MRI fusion system in the country for the whole body
- Passing R&D KDI preliminary feasibility for heavy particle accelerator Radiation
- Obtaining FDA accreditation as Preclinical Center (GLP)
2008
- Developing 30Mev cyclotron
- Building Radiation Irradiation Facility
2007
- Developing anti-cancer drug tolerance repressor (peptide substance)
2006
- Establishment of Southeast Regional Radiation Medical Center organization
- Building a KMS System
- Establishing a medical response system at the national level in case of Radioactive disaster

2005
- Establishing infrastructure to enforce Translational research
2004
- Declaration of KIRAMS VISION 2013
2003
- First clinical application of PET/CT in the country
2002
- Development of skin tissue regeneration technology and artificial skin
- Development of radiation exposure diagnosis gene marker
- Development of first cyclotron in the country
- Development of neutron radiography device
- First clinical application of cyber knife in the country
- Development of osteomatoid surgical reconstruction method
- Development of system for stereotaxic Radiation division treatment
2001
- Development of human body dosimetry technology
- Development of low-dose approach treatment device
- Development of radiation treatment enhancer (C8PS)t
- Development of anti-cancer treatment efficiency improvement method
- thru inhibition of particular enzyme of chromosome
- Development and commercialization/merchandising of GINSAN, anti-cancer
- immunological enhancer
- Development of gene treatment drug nuclear imaging method
- Localization of radiological medicine and medical supplies

Korea Institute Of Radiological & Medical Sciences